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p53 is active in murine stem cells and alters the transcriptome in a manner that is reminiscent of mutant p53
Since it was found that p53 is highly expressed in murine embryonic stem cells, it remained a mystery whether p53 is active in this cell type. We show that a significant part of p53 is localised in the nucleus of murine embryonic stem cells and that the majority of this nuclear p53 is bound to DNA....
Autores principales: | Yan, H, Solozobova, V, Zhang, P, Armant, O, Kuehl, B, Brenner-Weiss, G, Blattner, C |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669809/ https://www.ncbi.nlm.nih.gov/pubmed/25719246 http://dx.doi.org/10.1038/cddis.2015.33 |
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