Photoactivation of lysosomally sequestered sunitinib after angiostatic treatment causes vascular occlusion and enhances tumor growth inhibition

The angiogenesis inhibitor sunitinib is a tyrosine kinase inhibitor that acts mainly on the VEGF and PDGF pathways. We have previously shown that sunitinib is sequestered in the lysosomes of exposed tumor and endothelial cells. This phenomenon is part of the drug-induced resistance observed in the c...

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Detalles Bibliográficos
Autores principales: Nowak-Sliwinska, P, Weiss, A, van Beijnum, J R, Wong, T J, Kilarski, W W, Szewczyk, G, Verheul, H M W, Sarna, T, van den Bergh, H, Griffioen, A W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669819/
https://www.ncbi.nlm.nih.gov/pubmed/25675301
http://dx.doi.org/10.1038/cddis.2015.4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669819/
https://www.ncbi.nlm.nih.gov/pubmed/25675301
http://dx.doi.org/10.1038/cddis.2015.4

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