A pro-apoptotic function of iASPP by stabilizing p300 and CBP through inhibition of BRMS1 E3 ubiquitin ligase activity

The p53 family and its cofactors are potent inducers of apoptosis and form a barrier to cancer. Here, we investigated the impact of the supposedly inhibitory member of the apoptosis-stimulating protein of p53, iASPP, on the activity of the p53 homolog TAp73, and its cofactors p300 and CBP. We found...

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Detalles Bibliográficos
Autores principales: Kramer, D, Schön, M, Bayerlová, M, Bleckmann, A, Schön, M P, Zörnig, M, Dobbelstein, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669821/
https://www.ncbi.nlm.nih.gov/pubmed/25675294
http://dx.doi.org/10.1038/cddis.2015.17

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669821/
https://www.ncbi.nlm.nih.gov/pubmed/25675294
http://dx.doi.org/10.1038/cddis.2015.17

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