Cargando…

Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain

Mostrar otras versiones (1)

Neurodegeneration is a serious issue of neurodegenerative diseases including epilepsy. Downregulation of the chloride transporter KCC2 in the epileptic tissue may not only affect regulation of the polarity of GABAergic synaptic transmission but also neuronal survival. Here, we addressed the mechanis...

Descripción completa

Detalles Bibliográficos
Autores principales:	Winkelmann, A, Semtner, M, Meier, J C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669822/ https://www.ncbi.nlm.nih.gov/pubmed/26043076 http://dx.doi.org/10.1038/cddis.2015.127

Ejemplares similares

Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain
por: Winkelmann, A, et al.
Publicado: (2015)

KCC2 Chloride Transport Contributes to the Termination of Ictal Epileptiform Activity
por: Dzhala, Volodymyr I., et al.
Publicado: (2021)

Molecular architecture of potassium chloride co-transporter KCC2
por: Agez, Morgane, et al.
Publicado: (2017)

Both chloride-binding sites are required for KCC2-mediated transport
por: Becker, Lisa, et al.
Publicado: (2023)

Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?
por: Pozzi, Davide, et al.
Publicado: (2020)

KCC2 Much Chloride Might Not Be the Only Problem
por: Weston, Matthew
Publicado: (2019)

Cryo-EM structures of the full-length human KCC2 and KCC3 cation-chloride cotransporters
por: Chi, Ximin, et al.
Publicado: (2020)

Opposite temperature effect on transport activity of KCC2/KCC4 and N(K)CCs in HEK-293 cells
por: Hartmann, Anna-Maria, et al.
Publicado: (2011)

NKCC1 and KCC2 Chloride Transporters Have Different Membrane Dynamics on the Surface of Hippocampal Neurons
por: Pol, Erwan, et al.
Publicado: (2023)

Regulatory domain or CpG site variation in SLC12A5, encoding the chloride transporter KCC2, in human autism and schizophrenia
por: Merner, Nancy D., et al.
Publicado: (2015)

Structural changes in the extracellular loop 2 of the murine KCC2 potassium chloride cotransporter modulate ion transport
por: Hartmann, Anna-Maria, et al.
Publicado: (2021)

KCC2-dependent Steady-state Intracellular Chloride Concentration and pH in Cortical Layer 2/3 Neurons of Anesthetized and Awake Mice
por: Boffi, Juan C., et al.
Publicado: (2018)

Decreased Immunoreactivities and Functions of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Circling Mice
por: Pradhan, Jonu, et al.
Publicado: (2011)

Decreased Immunoreactivities of the Chloride Transporters, KCC2 and NKCC1, in the Lateral Superior Olive Neurons of Kanamycin-treated Rats
por: Suh, Myung-Whan, et al.
Publicado: (2012)

Noise-Induced Hearing Loss Alters Potassium-Chloride CoTransporter KCC2 and GABA Inhibition in the auditory centers
por: Parameshwarappa, Vinay, et al.
Publicado: (2023)

Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding
por: Doyon, Nicolas, et al.
Publicado: (2016)

N-terminal Serine Dephosphorylation Is Required for KCC3 Cotransporter Full Activation by Cell Swelling
por: Melo, Zesergio, et al.
Publicado: (2013)

Neuronal Chloride Regulation via KCC2 Is Modulated through a GABA(B) Receptor Protein Complex
por: Wright, Rebecca, et al.
Publicado: (2017)

Cryo-EM structure of the potassium-chloride cotransporter KCC4 in lipid nanodiscs
por: Reid, Michelle S, et al.
Publicado: (2020)

Structure of the human cation–chloride cotransport KCC1 in an outward-open state
por: Zhao, Yongxiang, et al.
Publicado: (2022)

Neurturin Evokes MAPK-Dependent Upregulation of Egr4 and KCC2 in Developing Neurons
por: Ludwig, Anastasia, et al.
Publicado: (2011)

Blocking Retinal Chloride Co-Transporters KCC2 and NKCC: Impact on Direction Selective ON and OFF Responses in the Rat’s Nucleus of the Optic Tract
por: Spoida, Katharina, et al.
Publicado: (2012)

Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
por: Dumon, Camille, et al.
Publicado: (2020)

Cation-Chloride Cotransporters KCC2 and NKCC1 as Therapeutic Targets in Neurological and Neuropsychiatric Disorders
por: Lam, Patricia, et al.
Publicado: (2023)

Kainate Receptors Coexist in a Functional Complex with KCC2 and Regulate Chloride Homeostasis in Hippocampal Neurons
por: Mahadevan, Vivek, et al.
Publicado: (2014)

Dose-dependent reversal of KCC2 hypofunction and phenobarbital-resistant neonatal seizures by ANA12
por: Carter, B. M., et al.
Publicado: (2018)

Crossing the Chloride Channel: The Current and Potential Therapeutic Value of the Neuronal K(+)-Cl(−) Cotransporter KCC2
por: Tillman, Luke, et al.
Publicado: (2019)

A Novel View on the Role of Intracellular Tails in Surface Delivery of the Potassium-Chloride Cotransporter KCC2
por: Friedel, Perrine, et al.
Publicado: (2017)

Dissection of Influenza A Virus M1 Protein: pH-Dependent Oligomerization of N-Terminal Domain and Dimerization of C-Terminal Domain
por: Zhang, Ke, et al.
Publicado: (2012)

KCC2-dependent subcellular E(Cl) difference of ON-OFF retinal ganglion cells in larval zebrafish
por: Zhang, Rong-wei, et al.
Publicado: (2013)

KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner
por: Awad, Patricia Nora, et al.
Publicado: (2018)

Presynaptic mechanisms of neuronal plasticity and their role in epilepsy
por: Meier, Jochen C., et al.
Publicado: (2014)

Reactive Neurogenesis and Down-Regulation of the Potassium-Chloride Cotransporter KCC2 in the Cochlear Nuclei after Cochlear Deafferentation
por: Tighilet, Brahim, et al.
Publicado: (2016)

Role of the neuronal K-Cl co-transporter KCC2 in inhibitory and excitatory neurotransmission
por: Chamma, Ingrid, et al.
Publicado: (2012)

Identification of KCC2 Mutations in Human Epilepsy Suggests Strategies for Therapeutic Transporter Modulation
por: Duy, Phan Q., et al.
Publicado: (2019)

Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odour discrimination
por: Gödde, Kathrin, et al.
Publicado: (2016)

A Cellular Mechanism of Learning-Induced Enhancement of Synaptic Inhibition: PKC-Dependent Upregulation of KCC2 Activation
por: Kfir, Adi, et al.
Publicado: (2020)

Changes in expression of the chloride homeostasis-regulating genes, KCC2 and NKCC1, in the blood of cirrhotic patients with hepatic encephalopathy
por: LI, JUN-JIE, et al.
Publicado: (2012)

A noninvasive optical approach for assessing chloride extrusion activity of the K–Cl cotransporter KCC2 in neuronal cells
por: Ludwig, Anastasia, et al.
Publicado: (2017)

Mycobacterium tuberculosis ClpC1 N-Terminal Domain Is Dispensable for Adaptor Protein-Dependent Allosteric Regulation
por: Marsee, Justin D., et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_65oeghnih91k0astotoo25valu