Nitric oxide stress and activation of AMP-activated protein kinase impair β-cell sarcoendoplasmic reticulum calcium ATPase 2b activity and protein stability

The sarcoendoplasmic reticulum Ca(2+) ATPase 2b (SERCA2b) pump maintains a steep Ca(2+) concentration gradient between the cytosol and ER lumen in the pancreatic β-cell, and the integrity of this gradient has a central role in regulated insulin production and secretion, maintenance of ER function an...

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Detalles Bibliográficos
Autores principales: Tong, X, Kono, T, Evans-Molina, C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669835/
https://www.ncbi.nlm.nih.gov/pubmed/26086963
http://dx.doi.org/10.1038/cddis.2015.154

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669835/
https://www.ncbi.nlm.nih.gov/pubmed/26086963
http://dx.doi.org/10.1038/cddis.2015.154

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