Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria

Acetate is a short-chain fatty acid secreted by Propionibacteria from the human intestine, known to induce mitochondrial apoptotic death in colorectal cancer (CRC) cells. We previously established that acetate also induces lysosome membrane permeabilization in CRC cells, associated with release of t...

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Detalles Bibliográficos
Autores principales: Oliveira, C S F, Pereira, H, Alves, S, Castro, L, Baltazar, F, Chaves, S R, Preto, A, Côrte-Real, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669836/
https://www.ncbi.nlm.nih.gov/pubmed/26086961
http://dx.doi.org/10.1038/cddis.2015.157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669836/
https://www.ncbi.nlm.nih.gov/pubmed/26086961
http://dx.doi.org/10.1038/cddis.2015.157

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