T-cell exhaustion in the tumor microenvironment

T-cell exhaustion was originally identified during chronic infection in mice, and was subsequently observed in humans with cancer. The exhausted T cells in the tumor microenvironment show overexpressed inhibitory receptors, decreased effector cytokine production and cytolytic activity, leading to th...

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Detalles Bibliográficos
Autores principales: Jiang, Y, Li, Y, Zhu, B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669840/
https://www.ncbi.nlm.nih.gov/pubmed/26086965
http://dx.doi.org/10.1038/cddis.2015.162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669840/
https://www.ncbi.nlm.nih.gov/pubmed/26086965
http://dx.doi.org/10.1038/cddis.2015.162

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