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Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val

Curcuma phaeocaulis Val. is used in Chinese Pharmacopoeia as health food and folk medicine for removing blood stasis, alleviating pain and tumor therapy. This research was aimed to explore and compare three main bioactivities including anti-oxidant, antitumor and anti-inflammatory activities between...

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Autores principales: Hou, Yan, Lu, Chuan-Li, Zeng, Qiao-Hui, Jiang, Jian-Guo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669906/
https://www.ncbi.nlm.nih.gov/pubmed/26648822
http://dx.doi.org/10.17179/excli2015-231
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author Hou, Yan
Lu, Chuan-Li
Zeng, Qiao-Hui
Jiang, Jian-Guo
author_facet Hou, Yan
Lu, Chuan-Li
Zeng, Qiao-Hui
Jiang, Jian-Guo
author_sort Hou, Yan
collection PubMed
description Curcuma phaeocaulis Val. is used in Chinese Pharmacopoeia as health food and folk medicine for removing blood stasis, alleviating pain and tumor therapy. This research was aimed to explore and compare three main bioactivities including anti-oxidant, antitumor and anti-inflammatory activities between the ethanol extract of C. Phaeocaulis and its fractions using different in vitro models. Firstly, 70 % ethanol was used to extract C. Phaeocaulis, and then the crude extract was re-extracted, resulting in petroleum ether (EZ-PE), ethyl acetate (EZ-EA), and water fractions (EZ-W), respectively, and then a series of index was detected. Results showed that all the extracts had medium DPPH radical scavenging activity when the concentration was 200 μg/ml and their DPPH radical scavenging activity was in a concentration-dependent manner. The extracts except ethanol extract of C. Phaeocaulis had almost no cytotoxicity to the survival of RAW264.7 cell when the concentration reached 80 μg/ml, and all of them had medium inhibitory effect on nitrite release. Extracts of C. Phaeocaulis had medium intensity antitumor activity, EZ-PE and EZ-EA fractions significantly inhibited the proliferation of four tumor cells (SMMC-7721 cell lines, HepG-2 cell lines, A549 cell lines and Hela cell lines). C. Phaeocaulis had antioxidant and anti-inflammatory activities, which did not carry out centralized phenomenon when re-extracted. EZ-PE and EZ-EA were active antitumor sites of C. Phaeocaulis.
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spelling pubmed-46699062015-12-08 Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val Hou, Yan Lu, Chuan-Li Zeng, Qiao-Hui Jiang, Jian-Guo EXCLI J Original Article Curcuma phaeocaulis Val. is used in Chinese Pharmacopoeia as health food and folk medicine for removing blood stasis, alleviating pain and tumor therapy. This research was aimed to explore and compare three main bioactivities including anti-oxidant, antitumor and anti-inflammatory activities between the ethanol extract of C. Phaeocaulis and its fractions using different in vitro models. Firstly, 70 % ethanol was used to extract C. Phaeocaulis, and then the crude extract was re-extracted, resulting in petroleum ether (EZ-PE), ethyl acetate (EZ-EA), and water fractions (EZ-W), respectively, and then a series of index was detected. Results showed that all the extracts had medium DPPH radical scavenging activity when the concentration was 200 μg/ml and their DPPH radical scavenging activity was in a concentration-dependent manner. The extracts except ethanol extract of C. Phaeocaulis had almost no cytotoxicity to the survival of RAW264.7 cell when the concentration reached 80 μg/ml, and all of them had medium inhibitory effect on nitrite release. Extracts of C. Phaeocaulis had medium intensity antitumor activity, EZ-PE and EZ-EA fractions significantly inhibited the proliferation of four tumor cells (SMMC-7721 cell lines, HepG-2 cell lines, A549 cell lines and Hela cell lines). C. Phaeocaulis had antioxidant and anti-inflammatory activities, which did not carry out centralized phenomenon when re-extracted. EZ-PE and EZ-EA were active antitumor sites of C. Phaeocaulis. Leibniz Research Centre for Working Environment and Human Factors 2015-06-12 /pmc/articles/PMC4669906/ /pubmed/26648822 http://dx.doi.org/10.17179/excli2015-231 Text en Copyright © 2015 Hou et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (http://creativecommons.org/licenses/by/4.0/) You are free to copy, distribute and transmit the work, provided the original author and source are credited.
spellingShingle Original Article
Hou, Yan
Lu, Chuan-Li
Zeng, Qiao-Hui
Jiang, Jian-Guo
Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val
title Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val
title_full Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val
title_fullStr Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val
title_full_unstemmed Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val
title_short Anti-inflammatory, antioxidant and antitumor activities of ingredients of Curcuma phaeocaulis Val
title_sort anti-inflammatory, antioxidant and antitumor activities of ingredients of curcuma phaeocaulis val
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669906/
https://www.ncbi.nlm.nih.gov/pubmed/26648822
http://dx.doi.org/10.17179/excli2015-231
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