Timosaponin B-II ameliorates diabetic nephropathy via TXNIP, mTOR, and NF-κB signaling pathways in alloxan-induced mice

BACKGROUND: Many synthesized drugs with clinical severe side effects have been used for diabetic nephropathy (DN) treatment. Therefore, it is urgent and necessary to identify natural and safe agents to remedy DN. Timosaponin B-II (TB-II), a major steroidal saponin constituent in Anemarrhena asphodel...

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Detalles Bibliográficos
Autores principales: Yuan, Yong-Liang, Guo, Chang-Run, Cui, Ling-Ling, Ruan, Shi-Xia, Zhang, Chun-Feng, Ji, De, Yang, Zhong-Lin, Li, Fei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669930/
https://www.ncbi.nlm.nih.gov/pubmed/26664046
http://dx.doi.org/10.2147/DDDT.S96435

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4669930/
https://www.ncbi.nlm.nih.gov/pubmed/26664046
http://dx.doi.org/10.2147/DDDT.S96435

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