RNA Sequence Analysis of Human Huntington Disease Brain Reveals an Extensive Increase in Inflammatory and Developmental Gene Expression

Huntington’s Disease (HD) is a devastating neurodegenerative disorder that is caused by an expanded CAG trinucleotide repeat in the Huntingtin (HTT) gene. Transcriptional dysregulation in the human HD brain has been documented but is incompletely understood. Here we present a genome-wide analysis of...

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Detalles Bibliográficos
Autores principales: Labadorf, Adam, Hoss, Andrew G., Lagomarsino, Valentina, Latourelle, Jeanne C., Hadzi, Tiffany C., Bregu, Joli, MacDonald, Marcy E., Gusella, James F., Chen, Jiang-Fan, Akbarian, Schahram, Weng, Zhiping, Myers, Richard H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670106/
https://www.ncbi.nlm.nih.gov/pubmed/26636579
http://dx.doi.org/10.1371/journal.pone.0143563

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670106/
https://www.ncbi.nlm.nih.gov/pubmed/26636579
http://dx.doi.org/10.1371/journal.pone.0143563

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