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Efficient Expression of Stabilized mRNAPEG-Peptide Polyplexes in Liver

The expression efficiency in liver following hydrodynamic delivery of in vitro transcribed mRNA was improved 2000-fold using a codon-optimized mRNA luciferase construct with flanking 3' and 5' human β-globin untranslated regions (UTR mRNA) over an un-optimized mRNA without β-globin UTRs. N...

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Detalles Bibliográficos
Autores principales: Crowley, Samuel T., Poliskey, Jacob A., Baumhover, Nicholas J., Rice, Kevin G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670273/
https://www.ncbi.nlm.nih.gov/pubmed/26125604
http://dx.doi.org/10.1038/gt.2015.68