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Efficient Expression of Stabilized mRNAPEG-Peptide Polyplexes in Liver

The expression efficiency in liver following hydrodynamic delivery of in vitro transcribed mRNA was improved 2000-fold using a codon-optimized mRNA luciferase construct with flanking 3' and 5' human β-globin untranslated regions (UTR mRNA) over an un-optimized mRNA without β-globin UTRs. N...

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Detalles Bibliográficos
Autores principales:	Crowley, Samuel T., Poliskey, Jacob A., Baumhover, Nicholas J., Rice, Kevin G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670273/ https://www.ncbi.nlm.nih.gov/pubmed/26125604 http://dx.doi.org/10.1038/gt.2015.68

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