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The Role of Aggregates of Therapeutic Protein Products in Immunogenicity: An Evaluation by Mathematical Modeling

Therapeutic protein products (TPP) have been widely used to treat a variety of human diseases, including cancer, hemophilia, and autoimmune diseases. However, TPP can induce unwanted immune responses that can impact both drug efficacy and patient safety. The presence of aggregates is of particular c...

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Detalles Bibliográficos
Autores principales: Yin, Liusong, Chen, Xiaoying, Tiwari, Abhinav, Vicini, Paolo, Hickling, Timothy P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670651/
https://www.ncbi.nlm.nih.gov/pubmed/26682236
http://dx.doi.org/10.1155/2015/401956