Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications

Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compar...

Descripción completa

Detalles Bibliográficos
Autores principales: Choudry, Fizzah Aziz, Frontini, Mattia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2016
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670691/
https://www.ncbi.nlm.nih.gov/pubmed/26681950
http://dx.doi.org/10.1155/2016/5797521
_version_ 1782404293502959616
author Choudry, Fizzah Aziz
Frontini, Mattia
author_facet Choudry, Fizzah Aziz
Frontini, Mattia
author_sort Choudry, Fizzah Aziz
collection PubMed
description Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriving clinical implications.
format Online
Article
Text
id pubmed-4670691
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-46706912015-12-17 Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications Choudry, Fizzah Aziz Frontini, Mattia Stem Cells Int Review Article Aging, chronic inflammation, and environmental insults play an important role in a number of disease processes through alterations of the epigenome. In this review we explore how age-related changes in the epigenetic landscape can affect heterogeneity within the haematopoietic stem cell (HSC) compartment and the deriving clinical implications. Hindawi Publishing Corporation 2016 2015-11-22 /pmc/articles/PMC4670691/ /pubmed/26681950 http://dx.doi.org/10.1155/2016/5797521 Text en Copyright © 2016 F. A. Choudry and M. Frontini. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Choudry, Fizzah Aziz
Frontini, Mattia
Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
title Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
title_full Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
title_fullStr Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
title_full_unstemmed Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
title_short Epigenetic Control of Haematopoietic Stem Cell Aging and Its Clinical Implications
title_sort epigenetic control of haematopoietic stem cell aging and its clinical implications
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670691/
https://www.ncbi.nlm.nih.gov/pubmed/26681950
http://dx.doi.org/10.1155/2016/5797521
work_keys_str_mv AT choudryfizzahaziz epigeneticcontrolofhaematopoieticstemcellaginganditsclinicalimplications
AT frontinimattia epigeneticcontrolofhaematopoieticstemcellaginganditsclinicalimplications

Ejemplares similares