Platelet-derived CXCL12 regulates monocyte function, survival, differentiation into macrophages and foam cells through differential involvement of CXCR4–CXCR7

Platelets store and release CXCL12 (SDF-1), which governs differentiation of hematopoietic progenitors into either endothelial or macrophage-foam cells. CXCL12 ligates CXCR4 and CXCR7 and regulates monocyte/macrophage functions. This study deciphers the relative contribution of CXCR4–CXCR7 in mediat...

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Detalles Bibliográficos
Autores principales: Chatterjee, M, von Ungern-Sternberg, S N I, Seizer, P, Schlegel, F, Büttcher, M, Sindhu, N A, Müller, S, Mack, A, Gawaz, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670914/
https://www.ncbi.nlm.nih.gov/pubmed/26583329
http://dx.doi.org/10.1038/cddis.2015.233

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670914/
https://www.ncbi.nlm.nih.gov/pubmed/26583329
http://dx.doi.org/10.1038/cddis.2015.233

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