Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101

Aberrant metabolic forms of the prion protein (PrP), membrane-associated (Ctm)PrP and cytosolic (cyPrP) interact with the cytosolic ubiquitin E3 ligase, Mahogunin Ring Finger-1 (MGRN1) and affect lysosomes. MGRN1 also interacts with and ubiquitinates TSG101, an ESCRT-I protein, involved in endocytos...

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Detalles Bibliográficos
Autores principales: Majumder, P, Chakrabarti, O
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670916/
https://www.ncbi.nlm.nih.gov/pubmed/26539917
http://dx.doi.org/10.1038/cddis.2015.257

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670916/
https://www.ncbi.nlm.nih.gov/pubmed/26539917
http://dx.doi.org/10.1038/cddis.2015.257

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