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Mahogunin regulates fusion between amphisomes/MVBs and lysosomes via ubiquitination of TSG101

Aberrant metabolic forms of the prion protein (PrP), membrane-associated (Ctm)PrP and cytosolic (cyPrP) interact with the cytosolic ubiquitin E3 ligase, Mahogunin Ring Finger-1 (MGRN1) and affect lysosomes. MGRN1 also interacts with and ubiquitinates TSG101, an ESCRT-I protein, involved in endocytos...

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Detalles Bibliográficos
Autores principales:	Majumder, P, Chakrabarti, O
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670916/ https://www.ncbi.nlm.nih.gov/pubmed/26539917 http://dx.doi.org/10.1038/cddis.2015.257

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