Unfolded protein response-induced dysregulation of calcium homeostasis promotes retinal degeneration in rat models of autosomal dominant retinitis pigmentosa

The molecular mechanism of autosomal dominant retinitis pigmentosa (ADRP) in rats is closely associated with a persistently activated unfolded protein response (UPR). If unchecked, the UPR might trigger apoptosis, leading to photoreceptor death. One of the UPR-activated cellular signaling culminatin...

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Detalles Bibliográficos
Autores principales: Shinde, V, Kotla, P, Strang, C, Gorbatyuk, M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2016
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670931/
https://www.ncbi.nlm.nih.gov/pubmed/26844699
http://dx.doi.org/10.1038/cddis.2015.325

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670931/
https://www.ncbi.nlm.nih.gov/pubmed/26844699
http://dx.doi.org/10.1038/cddis.2015.325

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