A positive feedback loop between Gli1 and tyrosine kinase Hck amplifies shh signaling activities in medulloblastoma

Sonic hedgehog (Shh) signaling is critical during normal development, and the abnormal activation of the Shh pathway is involved in many human cancers. As a target gene of the Shh pathway and as a transcription activator downstream of Shh signaling, Gli1 autoregulates and increases Shh signaling out...

Descripción completa

Detalles Bibliográficos
Autores principales: Shi, X, Zhan, X, Wu, J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670963/
https://www.ncbi.nlm.nih.gov/pubmed/26619401
http://dx.doi.org/10.1038/oncsis.2015.38

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670963/
https://www.ncbi.nlm.nih.gov/pubmed/26619401
http://dx.doi.org/10.1038/oncsis.2015.38

Ejemplares similares