Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature
Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that shows high penetrance with a wide variability in the phenotype. Prepubertal enlargement of the breast in male subjects affected by this condition is well known, but rarely reported. The present case report describes diagnosis and t...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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German Medical Science GMS Publishing House
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670967/ https://www.ncbi.nlm.nih.gov/pubmed/26668786 http://dx.doi.org/10.3205/iprs000070 |
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author | Friedrich, Reinhard E. Hagel, Christian Mautner, Victor-Felix |
author_facet | Friedrich, Reinhard E. Hagel, Christian Mautner, Victor-Felix |
author_sort | Friedrich, Reinhard E. |
collection | PubMed |
description | Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that shows high penetrance with a wide variability in the phenotype. Prepubertal enlargement of the breast in male subjects affected by this condition is well known, but rarely reported. The present case report describes diagnosis and therapy of unilateral gynaecomastia in a toddler showing integumental stigmata of NF1. Furthermore, the report provides a brief review of the literature concerning this finding in NF1. According to this review, the present case appears to be one of the youngest NF1-affected males affected by gynaecomastia that has been reported. |
format | Online Article Text |
id | pubmed-4670967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | German Medical Science GMS Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-46709672015-12-14 Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature Friedrich, Reinhard E. Hagel, Christian Mautner, Victor-Felix GMS Interdiscip Plast Reconstr Surg DGPW Article Neurofibromatosis type 1 (NF1) is an autosomal dominant disease that shows high penetrance with a wide variability in the phenotype. Prepubertal enlargement of the breast in male subjects affected by this condition is well known, but rarely reported. The present case report describes diagnosis and therapy of unilateral gynaecomastia in a toddler showing integumental stigmata of NF1. Furthermore, the report provides a brief review of the literature concerning this finding in NF1. According to this review, the present case appears to be one of the youngest NF1-affected males affected by gynaecomastia that has been reported. German Medical Science GMS Publishing House 2015-12-03 /pmc/articles/PMC4670967/ /pubmed/26668786 http://dx.doi.org/10.3205/iprs000070 Text en Copyright © 2015 Friedrich et al. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution 4.0 License. |
spellingShingle | Article Friedrich, Reinhard E. Hagel, Christian Mautner, Victor-Felix Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature |
title | Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature |
title_full | Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature |
title_fullStr | Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature |
title_full_unstemmed | Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature |
title_short | Unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature |
title_sort | unilateral gynaecomastia in a 16-month-old boy with neurofibromatosis type 1 – case report and brief review of the literature |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4670967/ https://www.ncbi.nlm.nih.gov/pubmed/26668786 http://dx.doi.org/10.3205/iprs000070 |
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