Stanniocalcin-1 inhibits thrombin-induced signaling and protects from bleomycin-induced lung injury

Thrombin-induced and proteinase-activated receptor 1 (PAR1)-mediated signaling increases ROS production, activates ERK, and promotes inflammation and fibroblast proliferation in bleomycin-induced lung injury. Stanniocalcin-1 (STC1) activates anti-oxidant pathways, inhibits inflammation and provides...

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Detalles Bibliográficos
Autores principales: Huang, Luping, Zhang, Lin, Ju, Huiming, Li, Qingtian, Pan, Jenny Szu-Chin, Al-Lawati, Zahraa, Sheikh-Hamad, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671147/
https://www.ncbi.nlm.nih.gov/pubmed/26640170
http://dx.doi.org/10.1038/srep18117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671147/
https://www.ncbi.nlm.nih.gov/pubmed/26640170
http://dx.doi.org/10.1038/srep18117

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