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Re-thinking miRNA-mRNA interactions: Intertwining issues confound target discovery

Despite a library full of literature on miRNA biology, core issues relating to miRNA target detection, biological effect, and mode of action remain controversial. This essay proposes that the predominant mechanism of direct miRNA action is translational inhibition, whereas the bulk of miRNA effects...

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Detalles Bibliográficos
Autor principal: Cloonan, Nicole
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4671252/
https://www.ncbi.nlm.nih.gov/pubmed/25683051
http://dx.doi.org/10.1002/bies.201400191