Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling

In this case report, we describe a refractory CMML case without eosinophilia harboring a PDGFRB rearrangement leading to a favorable response with imatinib. We believe this case demonstrates the utility of broad spectrum genomic profiling in refractory CMML cases as an opportunity to uncover additio...

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Detalles Bibliográficos
Autores principales: Bell, Gillian C., Padron, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672079/
https://www.ncbi.nlm.nih.gov/pubmed/26716078
http://dx.doi.org/10.1016/j.lrr.2015.07.002
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author Bell, Gillian C.
Padron, Eric
author_facet Bell, Gillian C.
Padron, Eric
author_sort Bell, Gillian C.
collection PubMed
description In this case report, we describe a refractory CMML case without eosinophilia harboring a PDGFRB rearrangement leading to a favorable response with imatinib. We believe this case demonstrates the utility of broad spectrum genomic profiling in refractory CMML cases as an opportunity to uncover additional treatment options.
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spelling pubmed-46720792015-12-29 Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling Bell, Gillian C. Padron, Eric Leuk Res Rep Article In this case report, we describe a refractory CMML case without eosinophilia harboring a PDGFRB rearrangement leading to a favorable response with imatinib. We believe this case demonstrates the utility of broad spectrum genomic profiling in refractory CMML cases as an opportunity to uncover additional treatment options. Elsevier 2015-09-24 /pmc/articles/PMC4672079/ /pubmed/26716078 http://dx.doi.org/10.1016/j.lrr.2015.07.002 Text en © 2015 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Bell, Gillian C.
Padron, Eric
Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling
title Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling
title_full Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling
title_fullStr Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling
title_full_unstemmed Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling
title_short Detection of a PDGFRB fusion in refractory CMML without eosinophilia: A case for broad spectrum tumor profiling
title_sort detection of a pdgfrb fusion in refractory cmml without eosinophilia: a case for broad spectrum tumor profiling
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672079/
https://www.ncbi.nlm.nih.gov/pubmed/26716078
http://dx.doi.org/10.1016/j.lrr.2015.07.002
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