Effects of Activating Mutations on EGFR Cellular Protein Turnover and Amino Acid Recycling Determined Using SILAC Mass Spectrometry

Rapid mutations of proteins that are targeted in cancer therapy often lead to drug resistance. Often, the mutation directly affects a drug's binding site, effectively blocking binding of the drug, but these mutations can have other effects such as changing the protein turnover half-life. Utiliz...

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Detalles Bibliográficos
Autores principales: Greig, Michael J., Niessen, Sherry, Weinrich, Scott L., Feng, Jun Li, Shi, Manli, Johnson, Ted O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672139/
https://www.ncbi.nlm.nih.gov/pubmed/26689952
http://dx.doi.org/10.1155/2015/798936

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672139/
https://www.ncbi.nlm.nih.gov/pubmed/26689952
http://dx.doi.org/10.1155/2015/798936

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