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Ultra-sensitive detection of tumorigenic cellular impurities in human cell-processed therapeutic products by digital analysis of soft agar colony formation

Contamination with tumorigenic cellular impurities is one of the most pressing concerns for human cell-processed therapeutic products (hCTPs). The soft agar colony formation (SACF) assay, which is a well-known in vitro assay for the detection of malignant transformed cells, is applicable for the qua...

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Detalles Bibliográficos
Autores principales: Kusakawa, Shinji, Yasuda, Satoshi, Kuroda, Takuya, Kawamata, Shin, Sato, Yoji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672267/
https://www.ncbi.nlm.nih.gov/pubmed/26644244
http://dx.doi.org/10.1038/srep17892