Peroxisome proliferator-activated receptor-α-mediated transcription of miR-301a and miR-454 and their host gene SKA2 regulates endothelin-1 and PAI-1 expression in sickle cell disease

Endothelin-1 (ET-1) and plasminogen activator inhibitor-1 (PAI-1) play important roles in pulmonary hypertension (PH) in sickle cell disease (SCD). Our previous studies show higher levels of placenta growth factor (PlGF) in SCD correlate with increased plasma levels of ET-1, PAI-1, and other physiol...

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Detalles Bibliográficos
Autores principales: Gonsalves, Caryn S., Li, Chen, Malik, Punam, Tahara, Stanley M., Kalra, Vijay K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672349/
https://www.ncbi.nlm.nih.gov/pubmed/26460070
http://dx.doi.org/10.1042/BSR20150190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672349/
https://www.ncbi.nlm.nih.gov/pubmed/26460070
http://dx.doi.org/10.1042/BSR20150190

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