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Identification of Major Signaling Pathways in Prion Disease Progression Using Network Analysis
Prion diseases are transmissible neurodegenerative diseases that arise due to conformational change of normal, cellular prion protein (PrP(C)) to protease-resistant isofrom (rPrP(Sc)). Deposition of misfolded Prp(Sc) proteins leads to an alteration of many signaling pathways that includes immunologi...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4672924/ https://www.ncbi.nlm.nih.gov/pubmed/26646948 http://dx.doi.org/10.1371/journal.pone.0144389 |