Multifaceted role of TREX2 in the skin defense against UV-induced skin carcinogenesis

TREX2 is a 3′-DNA exonuclease specifically expressed in keratinocytes. Here, we investigated the relevance and mechanisms of TREX2 in ultraviolet (UV)-induced skin carcinogenesis. TREX2 expression was up-regulated by chronic UV exposure whereas it was de-regulated or lost in human squamous cell carc...

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Detalles Bibliográficos
Autores principales: Manils, Joan, Gómez, Diana, Salla-Martret, Mercè, Fischer, Heinz, Fye, Jason M., Marzo, Elena, Marruecos, Laura, Serrano, Inma, Salgado, Rocío, Rodrigo, Juan P., Garcia-Pedrero, Juana M., Serafin, Anna M., Cañas, Xavier, Benito, Carmen, Toll, Agustí, Forcales, Sònia-Vanina, Perrino, Fred W., Eckhart, Leopold, Soler, Concepció
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673170/
https://www.ncbi.nlm.nih.gov/pubmed/26090614

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673170/
https://www.ncbi.nlm.nih.gov/pubmed/26090614

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