MYC amplifications in myeloma cell lines: correlation with MYC-inhibitor efficacy

In multiple myeloma, elevated MYC expression is related to disease initiation and progression. We found that in myeloma cell lines, MYC gene amplifications were common and correlated with MYC mRNA and protein. In primary cell samples MYC mRNA levels were also relatively high; however gene copy numbe...

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Detalles Bibliográficos
Autores principales: Holien, Toril, Misund, Kristine, Olsen, Oddrun Elise, Baranowska, Katarzyna Anna, Buene, Glenn, Børset, Magne, Waage, Anders, Sundan, Anders
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673192/
https://www.ncbi.nlm.nih.gov/pubmed/26087190

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673192/
https://www.ncbi.nlm.nih.gov/pubmed/26087190

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