NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells

The nucleophosmin (NPM1) activates cancer development and progression in many malignant tumors. However, the regulatory role and underlying mechanisms of NPM1 in pancreatic cancer are unknown. In this study, we showed that NPM1 was up-regulated in PDAC, which indicated a poor prognosis. We also iden...

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Detalles Bibliográficos
Autores principales: Zhu, Yi, Shi, Minmin, Chen, Hao, Gu, Jiangning, Zhang, Jiaqiang, Shen, Baiyong, Deng, Xiaxing, Xie, Junjie, Zhan, Xi, Peng, Chenghong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673277/
https://www.ncbi.nlm.nih.gov/pubmed/26068981
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author Zhu, Yi
Shi, Minmin
Chen, Hao
Gu, Jiangning
Zhang, Jiaqiang
Shen, Baiyong
Deng, Xiaxing
Xie, Junjie
Zhan, Xi
Peng, Chenghong
author_facet Zhu, Yi
Shi, Minmin
Chen, Hao
Gu, Jiangning
Zhang, Jiaqiang
Shen, Baiyong
Deng, Xiaxing
Xie, Junjie
Zhan, Xi
Peng, Chenghong
author_sort Zhu, Yi
collection PubMed
description The nucleophosmin (NPM1) activates cancer development and progression in many malignant tumors. However, the regulatory role and underlying mechanisms of NPM1 in pancreatic cancer are unknown. In this study, we showed that NPM1 was up-regulated in PDAC, which indicated a poor prognosis. We also identified NPM1could stimulate aerobic glycolysis and repress fructose-1, 6-bisphosphatase 1 (FBP1) in pancreatic cancer cells. Restoring FBP1 expression partially reversed the tumor-promoting effects of NPM1, while the loss of FBP1 in PDAC tissues was indicative of a poorer prognosis. In sum, NPM1 promotes aerobic glycolysis and tumor progression in patients with pancreatic cancer by inhibiting FBP1.
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spelling pubmed-46732772015-12-22 NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells Zhu, Yi Shi, Minmin Chen, Hao Gu, Jiangning Zhang, Jiaqiang Shen, Baiyong Deng, Xiaxing Xie, Junjie Zhan, Xi Peng, Chenghong Oncotarget Research Paper The nucleophosmin (NPM1) activates cancer development and progression in many malignant tumors. However, the regulatory role and underlying mechanisms of NPM1 in pancreatic cancer are unknown. In this study, we showed that NPM1 was up-regulated in PDAC, which indicated a poor prognosis. We also identified NPM1could stimulate aerobic glycolysis and repress fructose-1, 6-bisphosphatase 1 (FBP1) in pancreatic cancer cells. Restoring FBP1 expression partially reversed the tumor-promoting effects of NPM1, while the loss of FBP1 in PDAC tissues was indicative of a poorer prognosis. In sum, NPM1 promotes aerobic glycolysis and tumor progression in patients with pancreatic cancer by inhibiting FBP1. Impact Journals LLC 2015-06-05 /pmc/articles/PMC4673277/ /pubmed/26068981 Text en Copyright: © 2015 Zhu et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhu, Yi
Shi, Minmin
Chen, Hao
Gu, Jiangning
Zhang, Jiaqiang
Shen, Baiyong
Deng, Xiaxing
Xie, Junjie
Zhan, Xi
Peng, Chenghong
NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells
title NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells
title_full NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells
title_fullStr NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells
title_full_unstemmed NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells
title_short NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells
title_sort npm1 activates metabolic changes by inhibiting fbp1 while promoting the tumorigenicity of pancreatic cancer cells
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673277/
https://www.ncbi.nlm.nih.gov/pubmed/26068981
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