Combining BET and HDAC inhibitors synergistically induces apoptosis of melanoma and suppresses AKT and YAP signaling

Histone acetylation marks have an important role in controlling gene expression and are removed by histone deacetylases (HDACs). These marks are read by bromodomain and extra-terminal (BET) proteins and novel inhibitiors of these proteins are currently in clinical development. Inhibitors of HDAC and...

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Detalles Bibliográficos
Autores principales: Heinemann, Anja, Cullinane, Carleen, De Paoli-Iseppi, Ricardo, Wilmott, James S., Gunatilake, Dilini, Madore, Jason, Strbenac, Dario, Yang, Jean Y., Gowrishankar, Kavitha, Tiffen, Jessamy C., Prinjha, Rab K., Smithers, Nicholas, McArthur, Grant A., Hersey, Peter, Gallagher, Stuart J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673282/
https://www.ncbi.nlm.nih.gov/pubmed/26087189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673282/
https://www.ncbi.nlm.nih.gov/pubmed/26087189

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