A dominant-negative F-box deleted mutant of E3 ubiquitin ligase, β-TrCP1/FWD1, markedly reduces myeloma cell growth and survival in mice

Treatment of multiple myeloma with bortezomib can result in severe adverse effects, necessitating the development of targeted inhibitors of the proteasome. We show that stable expression of a dominant-negative F-box deleted (ΔF) mutant of the E3 ubiquitin ligase, SCF(β-TrCP/FWD1), in murine 5TGM1 my...

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Detalles Bibliográficos
Autores principales: Sharma, Ramaswamy, Williams, Paul J., Gupta, Anjana, McCluskey, Brandon, Bhaskaran, Shylesh, Muñoz, Steve, Oyajobi, Babatunde O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673288/
https://www.ncbi.nlm.nih.gov/pubmed/26009993

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673288/
https://www.ncbi.nlm.nih.gov/pubmed/26009993

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