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Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy

To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick’s limit. We find that in the biologically relevant range of parameters, if the imbalance between cell division and death is moder...

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Detalles Bibliográficos
Autores principales: Rodriguez-Brenes, Ignacio A., Wodarz, Dominik, Komarova, Natalia L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673423/
https://www.ncbi.nlm.nih.gov/pubmed/26647820
http://dx.doi.org/10.1038/srep17660