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Quantifying replicative senescence as a tumor suppressor pathway and a target for cancer therapy
To study quantitatively replicative senescence as a tumor suppressor mechanism, we investigate the distribution of a growing clonal cell population restricted by Hayflick’s limit. We find that in the biologically relevant range of parameters, if the imbalance between cell division and death is moder...
Autores principales: | Rodriguez-Brenes, Ignacio A., Wodarz, Dominik, Komarova, Natalia L. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673423/ https://www.ncbi.nlm.nih.gov/pubmed/26647820 http://dx.doi.org/10.1038/srep17660 |
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