Cargando…
Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway
The ability to biosynthetically produce chemicals beyond what is commonly found in Nature requires the discovery of novel enzyme function. Here we utilize two approaches to discover enzymes that enable specific production of longer-chain (C(5)–C(8)) alcohols from sugar. The first approach combines b...
Autores principales: | Mak, Wai Shun, Tran, Stephen, Marcheschi, Ryan, Bertolani, Steve, Thompson, James, Baker, David, Liao, James C., Siegel, Justin B. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Pub. Group
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673503/ https://www.ncbi.nlm.nih.gov/pubmed/26598135 http://dx.doi.org/10.1038/ncomms10005 |
Ejemplares similares
-
Corrigendum: Integrative genomic mining for enzyme function to enable engineering of a non-natural biosynthetic pathway
por: Mak, Wai Shun, et al.
Publicado: (2016) -
A new benchmark illustrates that integration of geometric constraints inferred from enzyme reaction chemistry can increase enzyme active site modeling accuracy
por: Bertolani, Steve J., et al.
Publicado: (2019) -
EvoMining reveals the origin and fate of natural product biosynthetic enzymes
por: Sélem-Mojica, Nelly, et al.
Publicado: (2019) -
A Benchmark for
Homomeric Enzyme Active Site Structure
Prediction Highlights the Importance of Accurate Modeling of Protein
Symmetry
por: Contreras, Stephanie C., et al.
Publicado: (2019) -
Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species
por: Wang, Xue, et al.
Publicado: (2018)