AF4 uses the SL1 components of RNAP1 machinery to initiate MLL fusion- and AEP-dependent transcription

Gene rearrangements generate MLL fusion genes, which can lead to aggressive leukemia. In most cases, MLL fuses with a gene encoding a component of the AEP (AF4 family/ENL family/P-TEFb) coactivator complex. MLL–AEP fusion proteins constitutively activate their target genes to immortalize haematopoie...

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Detalles Bibliográficos
Autores principales: Okuda, Hiroshi, Kanai, Akinori, Ito, Shinji, Matsui, Hirotaka, Yokoyama, Akihiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673504/
https://www.ncbi.nlm.nih.gov/pubmed/26593443
http://dx.doi.org/10.1038/ncomms9869

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673504/
https://www.ncbi.nlm.nih.gov/pubmed/26593443
http://dx.doi.org/10.1038/ncomms9869

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