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Effects of urine composition on epithelial Na(+) channel-targeted protease activity

We examined human urinary proteolytic activity toward the Epithelial Sodium Channel (ENaC). We focused on two sites in each of alpha and gamma ENaC that are targets of endogenous and exogenous proteases. We examined the effects of ionic strength, pH and urinary H(+)-buffers, metabolic intermediates,...

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Detalles Bibliográficos
Autores principales: Berman, Jonathan M, Awayda, Ryan G, Awayda, Mouhamed S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673640/
https://www.ncbi.nlm.nih.gov/pubmed/26564065
http://dx.doi.org/10.14814/phy2.12611