Aflibercept Traps Galectin-1, an Angiogenic Factor Associated with Diabetic Retinopathy

Vascular endothelial growth factor (VEGF)-A-driven angiogenesis contributes to various disorders including cancer and proliferative diabetic retinopathy (PDR). Among several VEGF-A blockers clinically used is aflibercept, a chimeric VEGFR1/VEGFR2-based decoy receptor fused to the Fc fragment of IgG1...

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Detalles Bibliográficos
Autores principales: Kanda, Atsuhiro, Noda, Kousuke, Saito, Wataru, Ishida, Susumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673700/
https://www.ncbi.nlm.nih.gov/pubmed/26648523
http://dx.doi.org/10.1038/srep17946

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673700/
https://www.ncbi.nlm.nih.gov/pubmed/26648523
http://dx.doi.org/10.1038/srep17946

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