The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington’s disease model

BACKGROUND: Although the genetic cause for Huntington’s disease (HD) has been known for over 20 years, the mechanisms that cause the neurotoxicity and behavioral symptoms of this disease are not well understood. One hypothesis is that N-terminal fragments of the HTT protein are the causative agents...

Descripción completa

Detalles Bibliográficos
Autores principales: Veldman, Matthew B., Rios-Galdamez, Yesenia, Lu, Xiao-Hong, Gu, Xiaofeng, Qin, Wei, Li, Song, Yang, X. William, Lin, Shuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673728/
https://www.ncbi.nlm.nih.gov/pubmed/26645399
http://dx.doi.org/10.1186/s13024-015-0063-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673728/
https://www.ncbi.nlm.nih.gov/pubmed/26645399
http://dx.doi.org/10.1186/s13024-015-0063-2

Ejemplares similares