Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells

BACKGROUND: Over-activated microglia and chronic neuroinflammation contribute to dopaminergic neuron degeneration and progression of Parkinson’s disease (PD). Leucine-rich repeat kinase 2 (LRRK2), a kinase mutated in autosomal dominantly inherited and sporadic PD cases, is highly expressed in immune...

Descripción completa

Detalles Bibliográficos
Autores principales: Russo, Isabella, Berti, Giulia, Plotegher, Nicoletta, Bernardo, Greta, Filograna, Roberta, Bubacco, Luigi, Greggio, Elisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673731/
https://www.ncbi.nlm.nih.gov/pubmed/26646749
http://dx.doi.org/10.1186/s12974-015-0449-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673731/
https://www.ncbi.nlm.nih.gov/pubmed/26646749
http://dx.doi.org/10.1186/s12974-015-0449-7

Ejemplares similares