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Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
BACKGROUND: Over-activated microglia and chronic neuroinflammation contribute to dopaminergic neuron degeneration and progression of Parkinson’s disease (PD). Leucine-rich repeat kinase 2 (LRRK2), a kinase mutated in autosomal dominantly inherited and sporadic PD cases, is highly expressed in immune...
Autores principales: | Russo, Isabella, Berti, Giulia, Plotegher, Nicoletta, Bernardo, Greta, Filograna, Roberta, Bubacco, Luigi, Greggio, Elisa |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673731/ https://www.ncbi.nlm.nih.gov/pubmed/26646749 http://dx.doi.org/10.1186/s12974-015-0449-7 |
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