Active site coupling in Plasmodium falciparum GMP synthetase is triggered by domain rotation

GMP synthetase (GMPS), a key enzyme in the purine biosynthetic pathway performs catalysis through a coordinated process across two catalytic pockets for which the mechanism remains unclear. Crystal structures of Plasmodium falciparum GMPS in conjunction with mutational and enzyme kinetic studies rep...

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Detalles Bibliográficos
Autores principales: Ballut, Lionel, Violot, Sébastien, Shivakumaraswamy, Santosh, Thota, Lakshmi Prasoona, Sathya, Manu, Kunala, Jyothirmai, Dijkstra, Bauke W., Terreux, Raphaël, Haser, Richard, Balaram, Hemalatha, Aghajari, Nushin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673825/
https://www.ncbi.nlm.nih.gov/pubmed/26592566
http://dx.doi.org/10.1038/ncomms9930

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673825/
https://www.ncbi.nlm.nih.gov/pubmed/26592566
http://dx.doi.org/10.1038/ncomms9930

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