RNA interference targeting carbohydrate sulfotransferase 3 diminishes macrophage accumulation, inhibits MMP-9 expression and promotes lung recovery in murine pulmonary emphysema

BACKGROUND: Chondroitin sulfate proteoglycans are an important mediators in inflammation and leukocyte trafficking. However, their roles in pulmonary emphysema have not been explored. In a murine model of elastase-induced pulmonary emphysema, we found increased carbohydrate sulfotransferase 3 (CHST3...

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Detalles Bibliográficos
Autores principales: Kai, Yoshiro, Tomoda, Koichi, Yoneyama, Hiroyuki, Yoshikawa, Masanori, Kimura, Hiroshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673861/
https://www.ncbi.nlm.nih.gov/pubmed/26646821
http://dx.doi.org/10.1186/s12931-015-0310-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673861/
https://www.ncbi.nlm.nih.gov/pubmed/26646821
http://dx.doi.org/10.1186/s12931-015-0310-7

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