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Single-cell analysis and stochastic modelling unveil large cell-to-cell variability in influenza A virus infection

Biochemical reactions are subject to stochastic fluctuations that can give rise to cell-to-cell variability. Yet, how this variability affects viral infections, which themselves involve noisy reactions, remains largely elusive. Here we present single-cell experiments and stochastic simulations that...

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Detalles Bibliográficos
Autores principales: Heldt, Frank S., Kupke, Sascha Y., Dorl, Sebastian, Reichl, Udo, Frensing, Timo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673863/
https://www.ncbi.nlm.nih.gov/pubmed/26586423
http://dx.doi.org/10.1038/ncomms9938