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Treatment-Resistant Major Depression: Rationale for NMDA Receptors as Targets and Nitrous Oxide as Therapy

Major depressive disorder (MDD) remains a huge personal and societal encumbrance. Particularly burdensome is a virulent subtype of MDD, treatment resistant major depression (TMRD), which afflicts 15–30% of MDD patients. There has been recent interest in N-methyl-d-aspartate receptors (NMDARs) as tar...

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Detalles Bibliográficos
Autores principales: Zorumski, Charles F., Nagele, Peter, Mennerick, Steven, Conway, Charles R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673867/
https://www.ncbi.nlm.nih.gov/pubmed/26696909
http://dx.doi.org/10.3389/fpsyt.2015.00172