An integrated structure- and system-based framework to identify new targets of metabolites and known drugs

Motivation: The inherent promiscuity of small molecules towards protein targets impedes our understanding of healthy versus diseased metabolism. This promiscuity also poses a challenge for the pharmaceutical industry as identifying all protein targets is important to assess (side) effects and reposi...

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Detalles Bibliográficos
Autores principales: Naveed, Hammad, Hameed, Umar S., Harrus, Deborah, Bourguet, William, Arold, Stefan T., Gao, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673972/
https://www.ncbi.nlm.nih.gov/pubmed/26286808
http://dx.doi.org/10.1093/bioinformatics/btv477

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673972/
https://www.ncbi.nlm.nih.gov/pubmed/26286808
http://dx.doi.org/10.1093/bioinformatics/btv477

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