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An integrated structure- and system-based framework to identify new targets of metabolites and known drugs
Motivation: The inherent promiscuity of small molecules towards protein targets impedes our understanding of healthy versus diseased metabolism. This promiscuity also poses a challenge for the pharmaceutical industry as identifying all protein targets is important to assess (side) effects and reposi...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4673972/ https://www.ncbi.nlm.nih.gov/pubmed/26286808 http://dx.doi.org/10.1093/bioinformatics/btv477 |