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A Hypothesis Concerning the Biphasic Dose-response of Tumors to Angiostatin and Endostatin
This manuscript proposes a hypothesis to explain the U-shaped dose-response observed for angiostatin and other high-molecular-weight drugs in various anti-cancer bio-assays. The dose-response curves for angiostatin and endostatin (measured as suppression of tumor growth) go through an optimum (i.e.,...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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SAGE Publications
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674172/ https://www.ncbi.nlm.nih.gov/pubmed/26675544 http://dx.doi.org/10.2203/dose-response.14-020.Parris |