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A feedforward loop of NLRC5 (de)ubiquitination keeps IKK–NF-κB in check
Many receptors signal via adaptors to the IKK–NF-κB axis, transducing extracellular cues to transcriptional regulation. In this issue, Meng et al. (2015. J. Cell Biol. http://dx.doi.org/10.1083/jcb.201505091) reveal that the IKK regulator NLRC5 shapes NF-κB activity through a feedforward loop of NLR...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674284/ https://www.ncbi.nlm.nih.gov/pubmed/26620908 http://dx.doi.org/10.1083/jcb.201511039 |