Destabilizing RET in targeted treatment of thyroid cancers

Metastatic differentiated thyroid cancers (DTC) are resistant to traditional chemotherapy. Kinase inhibitors have shown promise in patients with progressive DTC, but dose-limiting toxicity is commonplace. HSP90 regulates protein degradation of several growth-mediating kinases such as RET, and we hyp...

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Detalles Bibliográficos
Autores principales: Gild, M L, Bullock, M, Pon, C K, Robinson, B G, Clifton-Bligh, R J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674629/
https://www.ncbi.nlm.nih.gov/pubmed/26574568
http://dx.doi.org/10.1530/EC-15-0098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4674629/
https://www.ncbi.nlm.nih.gov/pubmed/26574568
http://dx.doi.org/10.1530/EC-15-0098

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